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I honestly prefer 
 Mage's Blessing over 
 Warrior's Blessing here on 
 Cthulhu, especially after the recent nerfs. If you still want to dedicate yourself to 
 Warrior's Blessing, feel free.
                    Mage's Blessing
                                    
                    Breastplate
                                    
                    Healing Potion
                                            
                    Multi Potion
                                    Breastplate of Valor is a fantastic first item on 
 Cthulhu, especially for his solo laning.
 Stone of Binding is a great tool to shred enemy protections and help yourself with boxing; this couples very well with 
 Cthulhu's Torment stacks.
 Bulwark of Hope then adds to the survivability of 
 Cthulhu during 
 Descend Into Madness, which is otherwise a dangerous ultimate as it lacks no escape and makes you a large target.
 Gem of Isolation helps to ensure you can confirm the root and extra damage of 
 The Mire whilst also adding even more utility to the remainder of 
 Cthulhu's kit. I sometimes consider building this earlier in the build if I feel the extra aggression is warranted and enough to compensate for the higher price.
 Ethereal Staff boosts 
 Cthulhu's already massive health pool while decreasing that of the enemies. This is a huge tool for 
 Cthulhu, and is often considered core to his builds in my experience.
 Mantle of Discord helps on top of 
 Bulwark of Hope to ensure that extra bit of survivability so that you can continue CC'ing and causing chaos in the enemy team without dying.
                    Breastplate of Valor
                                    
                    Shoes of Focus
                                    
                    Stone of Binding
                                    
                    Bulwark of Hope
                                    
                    Mantle of Discord
                                    
                    Gem of Isolation
                                    
                    Ethereal Staff
                                    
                    Elixir of Speed
                                    
 Bulwark of Hope, much like the explanation provided in the example build, is simply an excellent tool to allow 
 Cthulhu the time he needs to transform out of his ultimate and escape using 
 Rushing Terror after being bursted down. This extra layer of safety is absolutely worth the 2,300 gold.
 Genji's Guard is an alternative for 
 Breastplate of Valor if you are laning up against a magical solo such as 
 Cthulhu, 
 Baron Samedi, 
 Aphrodite, etc.
 Hide of the Urchin helps apply a constant shield to 
 Cthulhu which helps because of the enemy adc's high likelihood of running maximum-health based damage such as 
 Qin's Sais or other players building 
 Heartseeker/
 Soul Reaver.
 Void Stone adds a bit more bruiser capabilities to 
 Cthulhu's build. This reduces the enemy magical protections in an area, and helps ensure you deal more damage to enemies whilst taking less yourself.
 Oni Hunter's Garb is an interesting choice to build on 
 Cthulhu. If you find that you constantly dive the enemy team using your ultimate and are in the middle of fights, the damage mitigation can be very good to help keep you alive. Keep in mind for this item, however, that you are capable of reaching up to 30% damage mitigation already through the use of 
 Sanity Break.
 Pridwen is a choice I see a lot of people favor on 
 Cthulhu. This targets the same issue as 
 Bulwark of Hope, but I feel as if it is simply less effective. Where 
 Bulwark of Hope provides a shield at a time indicated by a percentage of your maximum health (which is high) and provides time to transform out of your ultimate, 
 Pridwen serves the purpose of buying time to escape AFTER transforming out of [[Descend into Madness].
                    Bulwark of Hope
                                    
                    Genji's Guard
                                    
                    Hide of the Urchin
                                    
                    Void Stone
                                    
                    Oni Hunter's Garb
                                    
                    Pridwen
                                    
 Breastplate of Valor is my go-to starting item on 
 Cthulhu. The cooldown reduction is incredible and allows his ultimate to be up every 70 seconds, whilst also remedying his problematic long ability cooldowns. Additionally, the item brings along nice physical protections to help in the solo lane and couples with the blue buff to resolve his mana problems entirely.
 Jade Emperor's Crown is an obvious bruiser tool to help lessen the damage output of enemies. This can help if you are being out damaged in your lane or the enemies have a lot of physical damage in their composition.
Lotus Crown is entirely up to you and your playstyle to determine whether or not you wish to pick it up. 
 Cthulhu's only healing ability is in the form of 
 Transfuse during his ultimate. However, that ability has the potential to reach and affect your entire team; this can result in an immediate boost of protections during a teamfight to your entire team, potentially swaying the course of battle.
 Mystical Mail provides some passive damage over time to enemies around you. This is not one of my first choices for a physical defensive item, but can be used to add a bit more of a passive bruising option during teamfights.
 Tyrannical Plate Helm is a fantastic item to pick up early game if you aren't winning lane as much as you would like. This item will help you out-clear the enemy solo laner and use minion damage to your advantage during boxing.
                    Breastplate of Valor
                                    
                    Jade Emperor's Crown
                                    
                    Tyrannical Plate Helm
                                    
                    Lotus Sickle
                                    
                    Mystical Mail
                                    [{Spectral Armor]] should absolutely replace 
 Hide of the Nemean Lion if the enemy ADC has opted to build more critical chance/strike damage than standard basic attack damage. If you deem it necessary however, it is not necessarily bad to build both.
 Pestilence and 
 Contagion are both anti-heal tools. If the enemy team has any healing which has caused problems for your team, these are excellent items that come with no drawbacks. If the enemy team has more physical damage, you would typically want to build 
 Contagion here. Similarly, if they have more magical damage, 
 Pestilence would be the better option.
 Stone of Gaia is a very underrated item right now, and is increasingly seeing use and play competitively. If the enemy team has any of the CC which will proc this effect (knock-ups, pulls, knockbacks, and grabs) then this could be a fantastic choice. Consider that the healing is all based off of maximum health, which is convenient provided 
 Cthulhu's naturally high base health (especially in 
 Descend Into Madness)and likelihood of further increasing it using items. Examples of gods that may motivate this purchase are 
 Bacchus, 
 Sobek, 
 Ganesha, 
 Awilix, and of course many others.
                    Spectral Armor
                                    
                    Pestilence
                                    
                    Contagion
                                    
                    Stone of Gaia
                                    I feel it necessary to mention here that upgraded 
 Cursed Ankh is probably one of the best relics right now, and it ALSO can mesh super well with 
 Descend Into Madness.
                        Teleport Fragment
                    
                        Shield of Thorns
                    
                        Magic Shell
                    
                        Cursed Ankh
                    
                        Horrific Emblem
                    
                    Ward
                                    
                    Sentry Ward
                                    Tap each threat level to view Cthulhu’s threats
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 ...... Cons ...... 
	
		 
	
- High health can result in heavy damage from items such as - Ultimate makes  | 
		
	
 Passive - Prey on Fear
Ability Description & Stats
	
 1 - Sanity Break
Ability Description & Stats
	
 2 - The Mire
Ability Description & Stats
	
 3 - Rushing Terror
Ability Description & Stats
	
 4 - Descend into Madness
Ability Description & Stats
	
 1 - Sever
Ability Description & Stats
	
 2 - Devastate
Ability Description & Stats
	
 3 - Transfuse
Ability Description & Stats
Let me know if there are any tips you have, or any recommendations you have for my guide! I'll be working on adding a general tips section within the next day or too as well.
Thank you!
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This is a very, very solid writeup and evaluation. I really like all of your explanations and considerations.
As we discussed to the side, I don't personally like the choice of
And as we also discussed, a different presentation of item choices might be better. It reads as very limiting for those that are checking this out just to see the build and don't read anything else.
But again, overall a great effort.