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Welcome to this simple guide on the friendly Scorpion Queen, Serqet! This build/guide is focused on getting a kill and getting out, with exceptional speed, not long sustained team-fights.
Pros:
Serqet's passive is an excellent finisher, dealing bonus damage based on the poison effects of your 1,2, and ultimate abilities
This ability is Serqet's bread and butter. It is your main source of damage, your best escape, and the dread of millions. It reduces protections, does lots of damage, and can Crit, which is what we are banking on with this guide. After doing the math with my preferred build, the damage of this ability(before protections), comes out to just under 2000 damage, if all three strikes hit and crit. Max this ASAP
This ability is a lifesaver, cutting of chasers and sowing discord among the enemy ranks with its confuse. Initiate with this, then immediately follow up with a 1 ability while they are CC'd, and watch the health drain away. Max this Second
Your 3 is your stealth ability, use it to set up ambushes, chase down an enemy, or escape. BUT, be wary that if you are hit with a hard CC while stealthed, you are screwed. Max this Last.
Serqet's ultimate, and this guide's namesake is a fantastic finisher, that will kill most Gods that are under half health, with the only exception being if they make it back to the fountain, or are a tank. This ability also can be used as an initiator, dealing damage and displacing an enemy, followed by your 2 ability for CC and your 1 ability for a finisher
On to the fine details of playing Serqet. Your main focus, is to pick your targets and catch them unprepared, either by themselves, or with one extra. You can initiate your assault with either a stealth launch with your 3 ability or your 2 from a distance then walk forwards. Save your one for when you are right on top of them, as it is your main damage dealer. After the initial burst, they should be near dead or near death. Basic attack to finish them off, or if that won't cut it, use your ult. Be aware of your surroundings at all times: nothing hurts worse than the fury of an entire team coming down on you.
Another approach would be to hang around the edges of team fights and pick of the stragglers trying to escape. Be wary of latecomers to the fight and the movement of the fight itself, as it is never good to find yourself in the middle of the fight.
One last and incredibly important part: KNOW YOUR LIMITS! Don't try to chase someone too far into enemy territory; know when to cut your losses and escape while you still have the chance.
Thank you all very much for looking at this guide. This was my first attempt at such a thing, and any feedback, advice, hate-mail, praise, or adoration would be approved and encouraged. Have fun crushing the life of your enemies!
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I would like to comment on your Serqet build. I generally agree with most of your build choices. I would say Deathbringer and probably Jotunn's Wrath are for sure core. I would also include Rage as core as well since it is cheaper and higher Crit strike chance than Malice and you need at least 2 Crit items for Serqet. So I have no issue with those.
I see the appeal of Hydra's Lament as her abilities make her really close to enemy gods so when you basic attack you gain the additional damage from Hydra's passive and also Serqet's passive Catalyst. The CDR on it is nice as well. I just feel that if you get it, you have to sacrifice something else in your build that you should probably get like Shifter's Shield or Titan's Bane. I would say this is situational depending enemy team makeup and if they are not building protections.
I only like Malice and Bloodforge from the final items. I would never get wind demon or Asi for her. You don't need the attack speed especially if you get Ninja Tabi. Bloodforge is okay and situational. Triple crit can work...but so expensive to get all online.
The biggest problem I have with your items is the lack of penetration. Yes, you get some from Jotunn's Wrath but it is not near enough when most assassins and hunters are building Shifter's Shieldand your damage to objectives would be lacking as well. Your attacks won't be as effective as they could be if they build one defensive item. I also wouldn't get Ninja Tabi over Warrior Tabi. I know it is your preference. But the extra attack speed from it, isn't necessarily needed as she has decent attack speed to begin with. Plus you want to get in, maybe hit a basic attack or 2 to proc Catalyst and get out. I feel you would have better luck with Titan's Bane, especially since it will be so cheap in patch 3.15, instead of either a 3rd crit item or Hydra's Lament. I would also suggest maybe getting Shifter's Shield as well. Since she is squishy and has to be close to do damage. A little defense goes a long way for her.
I compared your preferred build against a Serqet build of Warrior Tabi Rage Jotunn's Wrath Titan's Bane Deathbringer and Shifter's Shield. Should be able to see it here. The latter produces higher DPS and better overall damage while sacrificing only 10% CDR from subbing out Hydra's Lament. Not saying your build is bad by any means, but that it has its limits and can be more efficient as well.
Take my comments however you want as I am not trying to degrade your build by any means. If it works for you, it works for you. I have played Serqet a few times (little over 200 matches I think) and I actually build her tanky, because I am weird like that. I do have a guide on here if you want to look at it. Shameless plug. Which I suggest most of the items you do as possibilities so I generally agree with you...it is just a delicate balance is needed on what to build on Serqet or any god for that matter. Would like to hear your thoughts on my suggestions.
Edit: looking at the God builder, I stand by ninja, at least in the early game, as it adds more mana, allowing you to stay out longer. Should probably be replaced in the later game for that small damage boost.
Edit 2: I would also like to point out that your build would only have a crit chance of 55%, which is the main focus of my build(75%), allowing for a higher possibility of crit damage from serqet's 1 ability.
You should not need 75% critical strike chance over penetration. 55% crit chance should be quite enough since your dash strikes 3 times. And if it does not crit its not that big of a deal, since Catalyst does a lot of damage by itself if you combo it well. I used to just go Deathbringer alone on Serqet and rely mainly on focusing squishies and abusing Catalyst.
Also Ninja Tabi has very little mana to consider it good enough to buy it just for that stat, you buy it mainly for the attack speed. Warrior Tabi is a big early boost for an ability based assassin.
Keep in mind, most gods scale inherent physical protection. At level 20, Agni has 63, while hunters like Ah Muzen Cab] have 72. [[Titan's Bane exceeds the flat pen of Brawler's/Crusher even at that low protection level, and it just makes you more effective against all other, more tanky gods.