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Shoes of Focus - obvious reasons & the cooldown + mana is nice.
Lotus Crown - Passive works well with Chang'e.
Void Stone - power, protection, health.
Shoes of Focus
Lotus Crown
Void Stone
Breastplate of Valor - protections, mana, MP5, CDR.
Midgardian Mail - Good against basic attack based enemies like Bellona.
Spectral Armor - protections, mana, MP5, CCR. If the enemy solo laner goes crit for some reason. Unlikely, but who knows.
Breastplate of Valor
Midgardian Mail
Spectral Armor
Genji's Guard - Good against ability based magical solo laners, like Hera or Ra.
Pestilence - Direct counter to healers but not as effective as Divine Ruin.
Mantle of Discord - I know its both but whatever. Good overall defense, CDR, passive is nice to have.
Genji's Guard
Pestilence
Mantle of Discord
Gem of Isolation
Divine Ruin
Chronos' Pendant
Soul Reaver
Obsidian Shard
Shield of Regrowth - You will be speedy. The HP5, MP5, and CDR are nice additions as well.
Rod of Asclepius - I really think you should be picking this up 90% of the time. The passive works great with Chang'e, and you get power, health, and movement speed. Yummy
Stone of Gaia - Health, HP5, MP5. Excellent. Good against gods with knockups, like Geb, King Arthur, or Tyr.
Shield of Regrowth
Rod of Asclepius
Stone of Gaia
Shoes of Focus
Breastplate of Valor
Lotus Crown
Genji's Guard
Void Stone
Rod of Asclepius
Elixir of Speed
Gem of Isolation
Chronos' Pendant
Shoes of Focus
Lotus Crown
Rod of Asclepius
Void Stone
Mantle of Discord
Elixir of Speed
Obsidian Shard
Y
B
A
X
PROS
- Very high sustain with her passive, 
Jade Rabbit and her Moonflower Dance
- Large AoE abilities with low cooldowns.
- She has a built-in beads/aegis that is up every 9 seconds.
CONS
- Her abilities don't do much damage - she isn't a burst mage.
- She has no CC aside from her ultimate.
- She is extremely mana hungry, especially early game.
- Countered by anti-heal.
Jade Rabbit
Chang'e can purchase and sell items from anywhere on the map using her rabbit. This gives her very high sustain especially in the solo lane with a mana buff.
She can only purchase/sell one item at a time and must wait until her rabbit returns to receive the item & send it out again.
She also gains 25% movement speed with no back-pedal penalty when using her abilities - this makes it really easy to poke enemies without taking any damage yourself.
Crescent Moon Dance
This is her main damage/clear. It is an arc ability that deals damage to all enemies hit.
There isn't much to say about this ability, its good damage for poking enemies and clearing the wave.
Moonlit Waltz
This is her main escape. She performs an evasive dance, becoming immune to all damage, stuns, pulls, slows, etc., etc. She cannot use this if she is already stunned, silenced, or knocked up.
For every tick of damage avoided, she and her allies gain mana - up to 60 per tick.
While this ability does give her mana back, I really wouldn't recommend running into enemy abilities just to get mana because you are only immune for one second & have no other escape.
It's really important to get the timing of this ability right so you can avoid major damage through 
Da Ji or 
Ares' ult.
Moonflower Dance
This ability heals Chang'e and allies in the area while also damaging enemies. Something really important to remember: This also reduces the healing of nearby enemies by 50% for 4 seconds, making it good against life steal or other healers.
Waxing Moon
This is her ultimate - it is a line ability that damages and stuns enemies hit. The stun has a base length of one second, but an additional second is added per enemy hit, making it great in team fights.
It is important to use this for set up rather than killing enemies that are low health. The stun is much more valuable than the damage. It's also important not to be selfish with this ability since you will likely have it on a low cooldown anyways.
Crescent Moon Dance > Moonflower Dance or vice versa if the enemy can heal.
Waxing Moon > Crescent Moon Dance > Moonflower Dance or
Waxing Moon > Moonflower Dance > Crescent Moon Dance if the enemy can heal.
She doesn't really have set combos other than these due to her low cooldowns and how situational her ultimate is.
4.1 - I was soooo unhappy with the builds & so I just kinda ignored this entire guide for a while. Its probably still a little rough but hopefully a lot better
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Something like this:
I also believe that getting the speed pot and extra item is a lot better than a damage/defense buff that lasts 6 minutes. After the buff wears off you are 3k down with nothing to show for it instead of having a permanent item for approx. 4k total
Idk tho. thats just how I feel lol
For the Mid build swap cdr boots for pen boots as it's clearly a damage focused build yet you have no pen (and again, you cap cdr). Obsidian shard should also be presenet as an alternative item.
2nd thing,
for the mid build I wanted to keep 40% until very late game just bc its unrealistic to be getting a blue buff in mid & 500 is a big investment when you're trying to finish your build.
I also included more pen in the build, though I might also make an alternative build eventually