Relics: Start with Purfication Beads (To allow you to use rewind) if against Loki , Chaac , Chang'e, Bellona, Ullr, Kali , Hercules , Anhur etc...
Start with Sanctuary/Aegis (To allow you to negate Ultimate burst and still allow you to use Ultimate if you need to) if against Skadi, Bakasura, Hebo, Poseidon etc..
Bancrofts has become a very good first item choice for Chronos in duel, (and to some extent in conquest) due to the high early power for a cheap price along with the insane lifesteal from its passive, improving Chronos' viability in duel, I would recommend getting this item often , especially if against a Hunter, as your early boxing/poke will be much better.
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