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Yemoja's case, there are 2 I prefer on her.
Phantom Shell. This relic is really good on her because it compliments her kit. She's able to sustain her allies through healing and shielding them. This relic gives an extra form of sustain in a fight. It's also very good verse wall characters, such as 
Odin or 
Ymir.
Sundering Arc. Although I'm not the biggest fan of this relic, I can't argue with it's results. Sunder allows you to play aggressive early on the enemy camps, by being able to secure them. You can also secure objectives late game with it, or even finish off weak enemies in a fight. An all around great pick for those looking to be proactive and make plays.
Since Smite 2 only allows you to have 1 relic, and you can only pick that relic for the rest of the game, it's important to understand the effects of it. In Yemoja's case, there are 2 I prefer on her.
The first is Phantom Shell. This relic is really good on her because it compliments her kit. She's able to sustain her allies through healing and shielding them. This relic gives an extra form of sustain in a fight. It's also very good verse wall characters, such as Odin or Ymir.
The second is Sundering Arc. Although I'm not the biggest fan of this relic, I can't argue with it's results. Sunder allows you to play aggressive early on the enemy camps, by being able to secure them. You can also secure objectives late game with it, or even finish off weak enemies in a fight. An all around great pick for those looking to be proactive and make plays.
Phantom Shell
Sundering Arc
Yemoja loves going 
Selflessness because she loves to sustain her allies and this starter extends that, giving a shield to an ally that gets hard CC'd next to Yemoja. I would go this everytime on her, as there's no special exception to this rule.
Ring is a nice start to what will eventually be 
Prophetic Cloak, because you get cooldown from it. More on that in the full build section. But any of the t1 item starts are fine, you just need to see what you'll need more of in lane for that given game. Yemoja loves going Selflessness because she loves to sustain her allies and this starter extends that, giving a shield to an ally that gets hard CC'd next to Yemoja. I would go this everytime on her, as there's no special exception to this rule.
Ring is a nice start to what will eventually be Prophetic Cloak, because you get cooldown from it. More on that in the full build section. But any of the t1 item starts are fine, you just need to see what you'll need more of in lane for that given game.
Finally, we're gonna finish her start off with some health pots, to help sustain in lane, and some wards that we can use to gain sight on anyone coming to gank us. They'll be a section below on where to place the wards.
Selflessness
Ring
Health Potion
Vision Ward
Yemoja loves cooldown. This is because the more cooldown she has, the faster her Omi regens. So this build will focus on tankiness, survivability, and cooldown. There are other more damage style builds you can go on her, and I'll put some of those items in the "additional items section" if you're feeling crazy. But this is the main build I would go on her.
Heroism builds from Selflessness in the "starter" section. This is a great starter that shields your allies if they get CC'd (with a cooldown). This is probably one of the best support items in the game. Prophetic Cloak is really good on Yemoja because it gives her cooldown, which she loves. But it's also fairly easy to stack on her since he has range damaging abilities, and just overall great poke potential.
Stampede is a great item all around, but extremely good against comps that have a lot of slows. It's honestly a stat stick. It should be purchased in just about every support build with what it gives you right now for tankiness.
Talisman Of Purification I believe is a must in every support build. This item can be activated even while you're being CC'd. It's essentially a free beads for you and everyone around you, and it gives you cooldown. What's not to love? I would go this pretty much every game, building it no later then 3rd item.
Screeching Gargoyle gives you a ton of cooldown and magical protections. It's also an additional CC that you can have, and it's very good to help counter dive. On top of that, enemies who are silenced by this item become weaker, reducing their overall prots which means they take more damage. This is another item I have in almost every support build.
Spirit Robe is an all around great tanky item. It's very good against CC heavy comps, as it gives you more protections making you tankier when you get CC'd. On Yemoja in particular, if you go through your own hoops it'll actually proc this spirit robe effect. So not only are you getting prots from the hoop, but also from robe. This will allow you to get into the fight with like 70 more prots than you normally would have.
Hussar's Wings just like Stampede is a great stat stick. It's similar in that it gives slow immunity.... BUT PERMANENTLY. On top of that, the amount of protections and HP it gives is unreal. This is a great item to finish out a support build with.
Yemoja loves cooldown. This is because the more cooldown she has, the faster her Omi regens. So this build will focus on tankiness, survivability, and cooldown. There are other more damage style builds you can go on her, and I'll put some of those items in the "additional items section" if you're feeling crazy. But this is the main build I would go on her.
Heroism builds from Selflessness in the "starter" section. This is a great starter that shields your allies if they get CC'd (with a cooldown). This is probably one of the best support items in the game.
Prophetic Cloak is really good on Yemoja because it gives her cooldown, which she loves. But it's also fairly easy to stack on her since he has range damaging abilities, and just overall great poke potential.
Stampede is a great item all around, but extremely good against comps that have a lot of slows. It's honestly a stat stick. It should be purchased in just about every support build with what it gives you right now for tankiness.
Talisman Of Purification I believe is a must in every support build. This item can be activated even while you're being CC'd. It's essentially a free beads for you and everyone around you, and it gives you cooldown. What's not to love? I would go this pretty much every game, building it no later then 3rd item.
Screeching Gargoyle gives you a ton of cooldown and magical protections. It's also an additional CC that you can have, and it's very good to help counter dive. On top of that, enemies who are silenced by this item become weaker, reducing their overall prots which means they take more damage. This is another item I have in almost every support build.
Spirit Robe is an all around great tanky item. It's very good against CC heavy comps, as it gives you more protections making you tankier when you get CC'd. On Yemoja in particular, if you go through your own hoops it'll actually proc this spirit robe effect. So not only are you getting prots from the hoop, but also from robe. This will allow you to get into the fight with like 70 more prots than you normally would have.
Hussar's Wings just like Stampede is a great stat stick. It's similar in that it gives slow immunity.... BUT PERMANENTLY. On top of that, the amount of protections and HP it gives is unreal. This is a great item to finish out a support build with.
Heroism
Prophetic Cloak (Evolved)
Stampede
Talisman Of Purification
Screeching Gargoyle
Spirit Robe
Hussar's Wings
Gladiator's Shield can be subbed in for Prophetic Cloak. It gives cooldown, but it also allows Yemoja to do more damage. It's especially good on poke oriented characters, such as Yemoja, since it's extra damage tagged onto your damaging abilities.
Shogun's Ofuda is great if you have a lot of auto attack oriented allies on your team. This will provide them that extra stim that might just win you the fight.
Circe's Hexstone is great to engage with, especially if they have a lot of ranged lockdown, like roots. Yemoja doesn't have a natural escape, so this is a great substitute if you find yourself getting lockdown a lot. It's specifically needed into a character like Baron who is one of Yemoja's natural counters. You need to use it if you're getting blown up off his root, or pretty much anytime he ults, since Yemoja can't escape from Baron ult (even with her hoop).
Eye Of Providence is a great ward substitute if you don't find you need other items in your build. I would recommend this item more, but it does take 1 out of 3 of your total active slots. So I don't recommend this all the time.
These are gonna be some additional items that you can sub in and out of your main build if you'd like. Most of these are going to be more niche, and thus used in more specific situations.
Gladiator's Shield can be subbed in for Prophetic Cloak. It gives cooldown, but it also allows Yemoja to do more damage. It's especially good on poke oriented characters, such as Yemoja, since it's extra damage tagged onto your damaging abilities.
Shogun's Ofuda is great if you have a lot of auto attack oriented allies on your team. This will provide them that extra stim that might just win you the fight.
Circe's Hexstone is great to engage with, especially if they have a lot of ranged lockdown, like roots. Yemoja doesn't have a natural escape, so this is a great substitute if you find yourself getting lockdown a lot. It's specifically needed into a character like Baron who is one of Yemoja's natural counters. You need to use it if you're getting blown up off his root, or pretty much anytime he ults, since Yemoja can't escape from Baron ult (even with her hoop).
Eye Of Providence is a great ward substitute if you don't find you need other items in your build. I would recommend this item more, but it does take 1 out of 3 of your total active slots. So I don't recommend this all the time.
Gladiator's Shield
Shogun's Ofuda
Circe's Hexstone
Eye Of Providence
Y
B
A
X
Hey there, I go by Dashboarrd and I'm a Grandmaster Support Conquest player. I've competed in the SCC (Smite Challenger Circuit) and I have won SOC (Smite Open Circuit). I have also won plenty of gem tourneys during the weekends, such as Iced and Vulpis. I also hit Masters in Smite 2 and I competed in the Vegas tournament, making playoffs. I have put in many hours into Smite and in particular Yemoja. I hope this guide can give you some new direction with Yemoja if you're struggling with him, or just improve your overall Yemoja gameplay.
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