Isis mid S8

This is your optimal build on Isis at the beginning of the match. You can go sands of time but because you already have cooldown from your passive later in the game, Conduit gem would work better off for more damage. Magic focus gives you the options of building either spear of desolation for cooldown and penetration or divine ruin for antiheal. You can also start with a lost artifact to build rod of tahuti early on but I prefer the magic focus for the early pen and power. You can pick up two health potions instead of two mana potions or even some multi potions instead but with your high mana costing abilities, your mana sustain won't be the best early game so I'd suggest grabbing the two mana potions. Don't get me wrong, you'll always want to get your boots before your first item but you'll want the magic focus for that starting power rather than a little extra movement speed.

Of course if the enemy team has any form of hard healing, get divine ruin instead of spear. Because your passive provides a 10% CDR, you don't necessarily need shoes of focus because you'd be overcapping on CDR later in the game with chronos pendant. Shoes of the Magi gives you that early power and a little bit of lifesteal for early sustain along with the bonus hp5 from your passive. Spear of desolation gives you CDR along with penetration and power which come very useful early game when the mid laner and the jungler don't have their base protections online. Of course it is still useful later in the game with the CDR and the passive for more ultimate usage. Rod of Tahuti provides you with great mp5 along with the 10% penetration and an amazing passive seeing as how you should be able to get targets under 50% health very easily with your base ability damage.

This is your core items when you are in need of antiheal. You'll want to get Shoes of Focus rather than the Shoes of the Magi because it would give you that early CDR that you'd be sacrificing for Divine Ruin over Spear of Desolation. Divine ruin is a crucial early game item if you are going against a god with lots of healing (such as a Ra, Baron, Aphrodite, Hel, etc.) or lifesteal (such as Anubis, Hades, or anyone building any form of lifesteal). When deciding whether or not you want to build antiheal, you're mainly going to be looking at the Jungle, Mid, and Support roles. While an Aphrodite solo is considered a major healer, you won't be seeing her much in the early game stages. Along with this, you don't need to really focus on the Carry lifesteal. Earlygame, the carry will most likely be building Leather cowl, Devourer's Gauntlet, or even a Death's toll to provide them with early lifesteal. While this is a major form of healing, you don't necessarily need to build antiheal due to your high amount of burst damage. You'll be able to kill the carry in ganks before they have time to heal off of their AA's. Healer supports (such as Yemoja, sylvanus, terra, etc.) are a source of healing that you'd most definitely need antiheal for. Most of the time in the mid stages of the match, the support will either be in the duo lane or the mid lane so you'll be facing their healing very often. A lifesteal jungler (such as Ao kuang, Kali, or maybe Thanatos) isn't that big of a deal when it comes to antiheal. If you're facing a kali jungle, antiheal will definitely come in handy when she manages to kill her target. Ao kuang has lots of self healing and lifesteal built into his kit so watch out for that. Thanatos is a somewhat tricky one when it comes to building antiheal or not. While he does have a great heal from his 1 and his passive, he doesn't have much healing asides from that. If there is a healer on the opposing team you still need to build antiheal at some point of the match but you need to decide whether or not you need the antiheal earlier or later. And of course you'll be building Rod of tahuti for more overall damage and kill potential.

This is the optimal build on Isis when you don't have a strong need for antiheal. Soul gem will be your next item for the extra lifesteal, CDR and extra damage on your abilities. At this point, you'll have 20% lifesteal and the extra hp5 from your passive for extra sustain through the later stages of the game. You should have your passive fully stacked or at least close to being fully stacked by actively participating in teamfights and being around players who die. You'll be walking around with a bonus 20 hp5 and mp5 along with an extra 10% cooldown all from your passive. The soul gem passive is also going to allow for more ability damage and more healing within teamfights to you and your allies. Next, you'll want to pick up obsidian shard for the percent penetration. At this point of the game, most solo laners and supports will have lots of defensive items to help protect themselves from your attacks. With the percent penetration, you'll shred through their protections and shut them down easily. Paired with your Rod of Tahuti, you'll have the potential for 40% penetration. Finally you'll want to be grabbing Archmage's gem as your upgraded starter. You don't need to wait until you've grabbed your other items to grab this one. If you haven't finished obsidian shard but you just hit level 20, prioritize the starter item. The base stats of the item are pretty meh in my opinion providing you with some power and some more mp5. You'll have a bonus 20 mp5 from your passive already so you'll just be stacking up on extra mana regen. The reason that you'll grab this item over Gem of Focus is for it's amazing passive allowing you to do an extra 40% damage at full stacks. While the item did get recently nerfed from 2.5% damage per stack to 2% damage per stack, It's still an amazing power buff for the late game.

This build is more focused around cooldown and power rather than lifesteal. You'll need to grab chronos' pendant for the extra CDR along with the passive for extra CDR. Your previous items allow for more power and penetration to where your abilities are doing a good amount of damage. The CDR will help you dish out that damage more often and it also gives you more power for some more damage. You won't be getting soul gem because you don't have any other lifesteal to stack on top of the soul gem lifesteal. While there's not much of a difference between 12% and 20% lifesteal, it would be better to go for major CDR at this point as opposed to some CDR and some lifesteal.

This build is identical to the optimal build except that divine ruin is inserted between Tahuti and Soul gem. You should still get obsidian shard to replace the boots for the percent penetration.

There's not really gonna be a time where you're going to be getting anything other than these two relics. Beads can save you from CC allowing you to get away from a gank or a high damaging ability from an enemy. Aegis will help you survive through high damaging ultimates from the mid laner or the jungler.

In all honesty, at this point of the game there's not really a specific item that you should go. You could grab some defense to stay alive longer or even some more power but asides from that, there's really no telling what items you should build. If you want more lifesteal and penetration, grab a pythagoreans piece. You want to shred through the enemy's health bar? Grab a soul reaver. At this point in the match there's not really going to be one optimal item for you to grab. Hopefully at this point, you've played in the match long enough to know what you need more of for the endgame.