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After a lot of experimentation with Serqet I’ve found this build to work the best. Transcendence and Arondight are my two must haves for her. Building these two items after boots really boosts her effectiveness early game. After this I’d recommend something with flat pen, I prefer The Crusher for the attack speed. Next I’d go either life steal or defensive. I prefer Bloodforge due to its power and shields. I have Deathbringer as a boots replacement, but I’m still undecided about it. One crit item is weird, but even just the 25% chance seems to give her more damage potential than any other item. For a safe option this can easily be replaced by a defensive item.
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In my opinion Transcendence isn't even needed to be honest, it's not bad, I just think other items are more useful, I don't play much serqet, but if I was to play her I'd make a few changes;
First of all your start, Bumba's dagger and Boots 2, that's it, you don't need HoG and you don't need 4 multi pots.
Second of all, me personally, I'd drop the trans and probably go for a core 3 items of Warrior Tabi The Crusher Arondight
After this the build should be situational, but I think serqet is better as a bruiser, so I'd usually go for a Shifter's Shield then maybe a Pridwen or another damage item like Heartseeker