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Shoes of Focus
Book of Thoth
Chronos' Pendant
Polynomicon
Rod of Tahuti
Soul Reaver
Isis is one of my main gods right now i've experimented with the build a bit and this is what has the most benefit to me. Starting with Boots of Focus because of the recent buff it's more than viable for Isis with cooldown % it helps keep her 2s out. And Book of Thoth to start building magical damage at the end of the build this item will provide total of 19O power. after that our Chronos Pendant for more cooldown %. I messed around with a lot of items like gem of isolation and so on but ended up with Polynomicon; poly was extremely useful to me when putting out a quick stun or silence for an easy 1-2 punch dealing incredible damage. Rod of Tahuti for huge jump in power. And ending up with Soul Reaver very helpful for using her ult with multiple people especial with a hi health god inside as well as hitting enemies with any damaging abilities.
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